Amy Wang

Hi! I'm a senior scientist at Genentech, Prescient Design. I'm interested in problems at the intersection between biophysics, structural biology and machine learning. At Prescient, I work on de novo antibody design.

I did my PhD at Stanford University, where I studied mechanosensitive cell adhesion proteins using biophysical (molecular biology, single-molecule force spectroscopy) and computational approaches with Alex Dunn and Bill Weis. I also interned with Microsoft Research's BioML Team with Kevin Yang, Ava Amini, and Alex Lu to study how biophysical priors could improve ML models for protein property prediction. Additionally, I briefly worked with Ron Dror to study protein electrostatic binding interactions with MD simulations.

I received my bachelor's degree in Chemical Engineering with a minor in Polymers & Soft Matter at MIT. I worked in Brad Olsen's lab, where I studied the physics governing protein-block copolymer self-assembly, and in the Langer and Anderson labs, where I characterized protein-polymer interactions for drug delivery applications.

CV | Google Scholar | Twitter
amywangsci [at] gmail.com

Publications

	Multi-level force-dependent allosteric enhancement of αE-catenin binding to F-actin by vinculin N.A. Bax, A. Wang, D.L. Huang, S. Pokutta, A.R. Dunn, W.I. Weis Journal of Molecular Biology (2023) \| PDF
	Learning from physics-based features improves protein property prediction A. Wang, Alex X. Lu, Ava P. Amini, Kevin K. Yang Machine Learning in Structural Biology Workshop, NeurIPS 2022 \| PDF
	Mechanism of the cadherin-catenin F-actin catch bond interaction A. Wang, A.R. Dunn, W.I. Weis eLife (2022) \| PDF
	A retrievable implant for the long-term encapsulation and survival of therapeutic xenogeneic cells S. Bose, L.R. Volpatti, D. Thiono, V. Yesilyurt, C. McGladrigan, Y. Tang, A. Facklam, A. Wang, S. Jhunjhunwala, O. Veiseh, J. Hollister-Lock, C. Bhattacharya, G.C. Weir, D.L. Greiner, R. Langer, D.G. Anderson Nature Biomedical Engineering (2020) \| PDF
	Structure and mechanism of the cation–chloride cotransporter NKCC1 T.A. Chew, B.J. Orlando, J. Zhang, N.R. Latorraca, A. Wang, S.A. Hollingsworth, D.H. Chen, R.O. Dror, M. Liao, L. Feng Nature* (2019) \| PDF
	Predicting protein–polymer block copolymer self-assembly from protein properties A. Huang, J.M. Paloni, A. Wang, A.C. Obermeyer, H.V. Sureka, H. Yao, B.D. Olsen Biomacromolecules (2019) \| PDF
	Design of insulin-loaded nanoparticles enabled by multistep control of nanoprecipitation and zinc chelation S. Chopra, N. Bertrand, J. Lim, A. Wang, O. Farokhzad, R. Karnik ACS Applied Materials & Interfaces (2017) \| PDF Patent Filed October 7, 2015.

Awards and Affiliations

University Nominee for the 2023 Schmidt Science Fellows Program
Valuation of Public Companies in the Life Sciences Pitch Competition (INDE209) - First Place (2020)
NSF Graduate Research Fellowship (2018-2023)
Stanford ChEM-H Chemistry/Biology Interface Predoctoral Training Program (2018-2023)
Stanford Graduate Fellowship (2018-2023)
MIT Tau Beta Pi (2017)
MIT Chemical Engineering Departmental BP Academic Achievement Award (2016)

Webpage design courtesy of Jon Barron.

	Multi-level force-dependent allosteric enhancement of αE-catenin binding to F-actin by vinculin N.A. Bax, A. Wang, D.L. Huang, S. Pokutta, A.R. Dunn, W.I. Weis Journal of Molecular Biology (2023) \| PDF
	Learning from physics-based features improves protein property prediction A. Wang, Alex X. Lu, Ava P. Amini, Kevin K. Yang Machine Learning in Structural Biology Workshop, NeurIPS 2022 \| PDF
	Mechanism of the cadherin-catenin F-actin catch bond interaction A. Wang, A.R. Dunn, W.I. Weis eLife (2022) \| PDF
	A retrievable implant for the long-term encapsulation and survival of therapeutic xenogeneic cells S. Bose, L.R. Volpatti, D. Thiono, V. Yesilyurt, C. McGladrigan, Y. Tang, A. Facklam, A. Wang, S. Jhunjhunwala, O. Veiseh, J. Hollister-Lock, C. Bhattacharya, G.C. Weir, D.L. Greiner, R. Langer, D.G. Anderson Nature Biomedical Engineering (2020) \| PDF
	Structure and mechanism of the cation–chloride cotransporter NKCC1 T.A. Chew, B.J. Orlando, J. Zhang, N.R. Latorraca, A. Wang, S.A. Hollingsworth, D.H. Chen, R.O. Dror, M. Liao, L. Feng Nature* (2019) \| PDF
	Predicting protein–polymer block copolymer self-assembly from protein properties A. Huang, J.M. Paloni, A. Wang, A.C. Obermeyer, H.V. Sureka, H. Yao, B.D. Olsen Biomacromolecules (2019) \| PDF
	Design of insulin-loaded nanoparticles enabled by multistep control of nanoprecipitation and zinc chelation S. Chopra, N. Bertrand, J. Lim, A. Wang, O. Farokhzad, R. Karnik ACS Applied Materials & Interfaces (2017) \| PDF Patent Filed October 7, 2015.